What's The Difference Between An IgE vs. non-IgE Mediated Food Allergy?

Untitled design.png

IgE mediated food allergies
* Risk of anaphylaxis.
* Hives.
* Swelling of mouth, lips or throat.
* Difficulty breathing.
* Could be fatal.
* Treat with epipen.


Non-IgE mediated allergic reaction
* Mostly gut related symptoms (diarrhea, vomiting).
* Does not lead to anaphylaxis.
* Does not involve hives.
* FPIES (food protein induced enterocolitis).
* Severe FPIES leads to vomiting till shock.
* Cow's milk protein allergy (non-IgE).
* Malabsorption and failure to thrive.


Both impact food allergy families significantly. More money to buy special food, fear and anxiety, lack of food freedom, more time and labour spent on preparing special foods. Both groups need to avoid the allergen.


Both are very different from food intolerance. I know some would refer to non-IgE food allergies as "food intolerance" and IgE mediated allergies as "true food allergies". This language is problematic.


It implies that non-IgE mediated allergies are not true food allergies and you can "get away with having just a little" like lactose intolerance. This also implies that non-IgE reactions are not so serious, when in fact, an acute FPIES reaction could be violent vomiting until shock requiring immediate medical attention.